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| Clinical data | |
|---|---|
| Trade names | Cataflam, Voltaren, see trade names [1] |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a689002 |
| Pregnancy category | AU: C US: C (Risk not ruled out) in 1st and 2nd trimester, D in 3rd trimester, |
| Routes of administration | oral, rectal, intramuscular, intravenous (renal- and gallstones), topical |
| ATC code | D11AX18 ( WHO ) M01AB05 ( WHO ), M02AA15 ( WHO ), S01BC03 ( WHO ) |
| Legal status | |
| Legal status | AU: S2 (Pharmacy only) – S4, UK: POM (Prescription only) (P for topical formulation), ℞-only in most preparations/countries, limited OTC in some countries, manufacture and veterinary use is banned in India, Nepal, and Pakistan due to imminent extinction of local vultures |
| Pharmacokinetic data | |
| Protein binding | More than 99% |
| Metabolism | hepatic, oxidative, primarily by CYP2C9, also by CYP2C8, CYP3A4, as well as conjugative by glucuronidation (UGT2B7) and sulfation; [2] no active metabolites exist |
| Elimination half-life | 1.2–2 hr (35% of the drug enters enterohepatic recirculation) |
| Excretion | 40% biliary 60% urine |
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